All Tests

B-Cell Gene Rearrangement IGH

PCR assay used to detect clonalimmunoglobulin receptor heavy chain (IGH) gene rearrangements in regions1,2,3 and joining regions; to help diagnosing B-cell neoplasms, to detect andevaluate residual cancer cells and to evaluate the effectiveness of treatment.Detection of clonal IgH gene rearrangements by PCR of IgH framework regions 1, 2, 3 and joining regions.

Synonyms
Turnaround Time
8 days
Methodology
Molecular
Specimen Requirements

Whole blood (3-5 mL), Bonemarrow (1-2 mL), in Lavender-top (EDTA) tube.

Formalin-fixed,paraffin-embedded (FFPE) tissue block (preferred) or slides (1 H&E slide,plus 5-10 unstained slides cut at 5+ microns). Please use positively charged slides and 10% NBF fixative. Do not use zinc fixatives.

Fixation: Fresh tissue, two pieces minimum,0.2 cm3 in RPMI medium.

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Storage and Transportation

-Use cold pack but not in direct contact with specimen. Not suitable for freeze & hold option.

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CPT Codes
81261