Brachyury (RBT-TBXT)

Brachyury is a protein encoded by the T gene in humans. It acts as a transcription factor and is part of the T-box family of genes. This protein plays a conserved role in forming the midline of bilaterally symmetrical organisms and helps establish the anterior-posterior body axis, a function observed in both chordates and mollusks. Although the number of cervical vertebrae is usually consistent among mammals, a spontaneous mutation in this gene, known as vertebral and spinal dysplasia (VSD), has been linked to the presence of six or fewer cervical vertebrae instead of the typical seven.

Synonyms

Turnaround Time

24 hrs

Methodology

IHC

Specimen Requirements

Accepted Specimen Types:

Formalin-fixed paraffin-embedded (FFPE) tissue sections
Frozen tissue sections (acetone-fixed)
Acetone-fixed cell preparations

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Storage and Transportation

Storage before shipping:

FFPE blocks or slides can be stored at room temperature
Frozen sections must be kept frozen at -20°C or colder until shipped
Avoid repeated freeze-thaw cycles

Transportation instructions:

FFPE blocks and unstained slides can be shipped at room temperature in a secure, padded container
Frozen tissue or cell preparations must be shipped on dry ice in an insulated container
Include appropriate documentation and clearly label the specimen type and required test

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CPT Codes

88342 | 88341