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A follicular B-cell surface marker expressed in early lymphoid progenitors and germinal center cells. Commonly positive in precursor B-lymphoblastic lymphoma, Burkitt lymphoma, follicular lymphoma, some diffuse large B-cell lymphomas, and multiple myeloma; less frequent in precursor T-lymphoblastic leukemia/lymphoma. Also expressed in various non-hematopoietic tumors (e.g., atypical fibroxanthoma, endometrial stromal sarcoma) and in normal tissues such as breast myoepithelial cells, bile canaliculi, fibroblasts, and the brush border of kidney and gut epithelium.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.