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A protein kinase transmembrane receptor that is expressed in tissues and cells such as tissue mast cells, skin basal cells, melanocytes, breast glandular epithelial cells, dermal sweat gland, esophageal glands, and testicular and ovarian interstitial cells. It is a marker of gastrointestinal stromal tumors and is also expressed in melanomas, breast carcinomas, and small cell lung carcinoma. A mutant form of gastrointestinal stromal tumor is the target of imatinib mesylate therapy.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.