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A cytoplasmic and cell-surface protein involved in phagocytosis, chemotaxis, and bactericidal activity. Strongly expressed in granulocytes, with weaker expression in monocytes/histiocytes, Reed-Sternberg cells, some epithelial cells, and occasionally large B- and T-cell lymphomas. Useful in identifying Hodgkin lymphoma.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.