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A cell surface protein expressed on a subset of peripheral blood cells, B lymphocytes, EBV-transformed B-lymphoblastoid lines, and many follicular dendritic cells. Useful for distinguishing CLL/SLL from other B-cell neoplasms and often strongly coexpressed with CD5 on these B cells.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.