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A cell surface protein that serves as the interleukin-2 receptor. Strongly expressed in neoplastic T cells of adult T-cell leukemia/lymphoma, anaplastic large cell lymphoma, hairy cell leukemia, classical Hodgkin lymphoma, and some peripheral T-cell lymphomas. Aberrant expression on mast cells aids in diagnosing systemic mastocytosis.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.