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A cytoplasmic and cell surface protein expressed on activated B and T cells. Strongly expressed in anaplastic large cell lymphoma and variably in infectious mononucleosis, HIV/HTLV-1/EBV/HHV8/hepatitis B–infected lymphocytes, Reed-Sternberg cells, lymphomatoid papulosis, peripheral T-cell lymphomas, most classical Hodgkin lymphomas, and embryonal cell tumors.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.