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A cell surface protein highly expressed on helper T cells and at lower levels on monocytes, Langerhans cells, and dendritic cells. Absent in immature thymocytes. Most mature T-cell lymphomas are positive, except aggressive NK-cell leukemia, extranodal NK/T-cell lymphoma, γδ T-cell lymphomas, and enteropathy-associated T-cell lymphoma. Functions as the HIV receptor.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.