CD45 LCA

A family of membrane glycoproteins variably expressed on all hematopoietic cells, including lymphocytes, monocytes, and eosinophils, but absent on normal and malignant non-hematopoietic tissues. Aberrant loss of CD45 expression occurs in some precursor B-lymphoblastic leukemias, most multiple myelomas, and nearly all cases of classical Hodgkin lymphoma, where Reed-Sternberg cells and their variants are typically negative.