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Identifies a cytoplasmic and lysosomal-associated protein expressed by normal and neoplastic monocytes/histiocytes, including Langerhans cells. CD68 is a useful marker for macrophages in various tissues such as spleen, liver, lung, gut, and bone marrow. It also stains myeloid precursors and granulocytes and is positive in chronic and acute myeloid leukemias, histiocytic neoplasms, granular cell tumors, and some melanomas and renal cell carcinomas.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.