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Marks a protein in dense-core granules of neuroendocrine cells. Useful for identifying carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine neoplasms, though less sensitive than synaptophysin for high-grade tumors.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain),baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.