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Identifies a cell surface protein selectively expressed in gastrointestinal stromal tumors (GIST) and complements other markers such as c-Kit (CD117). It detects most c-Kit–negative and PDGFRA-mutated GISTs that may still respond to imatinib therapy. DOG1 shows fewer cross-reactions with mesenchymal, epithelial tumors, and melanomas, improving GIST diagnostic accuracy.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.