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Identifies a transmembrane cell-cell adhesion protein that is expressed in epithelial cells. It stains positively in glandular epithelium and in adenocarcinomas of the lung, gastrointestinal tract, and ovary. E-cadherin is useful in distinguishing adenocarcinoma from mesothelioma, and in differentiating lobular carcinoma (which shows loss or marked reduction of expression) from ductal carcinoma of the breast.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.