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Identifies EBV latent membrane protein-1, a cell surface-associated protein encoded by the EBV genome and expressed by a subset of EBV-infected B-cells. It shows strong reactivity in EBV-positive lymphoblastoid cell lines, EBV-infected immunoblasts in infectious mononucleosis, and certain EBV-associated neoplasms such as Hodgkin lymphoma. LMP-1 is a less sensitive marker compared to EBER for detecting EBV infection.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.