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Identifies the epidermal growth factor receptor (EGFR) protein, a transmembrane receptor tyrosine kinase involved in cell growth and differentiation. The 43B2 clone specifically detects the wild-type EGFR protein and is expressed in various epithelial tissues and tumors, including lung, breast, colorectal, and squamous cell carcinomas. EGFR overexpression is often associated with tumor aggressiveness and poor prognosis and may guide targeted therapy decisions using EGFR inhibitors.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not indirect contact with specimen.