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ERG is a member of the ETS transcription factor gene family and is strongly overexpressed in endothelial cells and is a highly specific and sensitive marker of vascular neoplasms, and expression has been shown to be a highly specific marker for prostate cancer. ERG expression is lacking in a wide variety of normal epithelial tissues and tumors, therefore detection of ERG by IHC is a useful tool for diagnosing prostate cancer or determining prostatic origin.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.