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Identifies von Willebrand factor, a protein synthesized by endothelial cells and stored in Weibel-Palade bodies. It is also present in platelets and megakaryocytes. Immunohistochemical detection is useful for identifying endothelial cells, diagnosing vascular neoplasms, and detecting vascular invasion by tumors.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE)tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.