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A highly conserved actin-bundling protein expressed mainly in dendritic cells. Fascin is negative in most lymphoid, myeloid, and plasma cells, but positive in Reed-Sternberg cells of Hodgkin lymphoma, helping to distinguish it from anaplastic large cell lymphoma. EBV infection may induce fascin expression in B-cells.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.