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A nuclear transcription factor expressed primarily in ovarian granulosa cells. FOXL2 is a key regulator of ovarian development and function and is useful in identifying sex cord-stromal tumors of the ovary, particularly adult granulosa cell tumors. It helps differentiate these tumors from other ovarian neoplasms.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not indirect contact with specimen.