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A cytoplasmic adaptor protein involved in signal transduction from receptor tyrosine kinases, including MET and EGFR. Gab1 plays a role in cell growth, differentiation, and survival. Immunohistochemical detection of Gab1 can aid in studying tumors with dysregulated MET or EGFR signaling pathways, including certain carcinomas and sarcomas.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not indirect contact with specimen.