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A zinc finger nuclear transcription factor of the GATA family, GATA3 is a sensitive marker for breast and bladder carcinomas. It regulates luminal cell differentiation in the mammary gland and is associated with ER expression in breast cancer. GATA3 also stains subsets of squamous cell carcinomas, skin adnexal tumors, mesotheliomas, and salivary gland tumors, but is negative in prostate and renal carcinomas.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.