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A cytoplasmic enzyme that catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine synthetase is expressed in hepatocytes, particularly around the central veins, and is a useful marker for identifying hepatocellular lesions, including hepatocellular carcinoma, and for assessing liver zonation and metabolic patterns.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not indirect contact with specimen.