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A cytotoxic protein expressed in cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells. Granzyme B is useful for identifying tumors of CTL or NK-cell origin and for differentiating them from other hematolymphoid neoplasms. It is commonly used in the evaluation of anaplastic large cell lymphoma, large granular lymphocytic leukemia, hepatosplenic T-cell lymphoma, intestinal T-cell lymphoma, NK-like T-cell lymphoma, NK-cell lymphoma, nasal T/NK-cell lymphoma, and subcutaneous panniculitic T-cell lymphoma.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.