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Identifies a nuclear protein involved in the modification of DNA by protein Histone H3 and this antibody is used to identify malignant peripheral nerve sheet tumors (MPNST), about half of which show complete loss of expression of this nuclear protein. This loss of expression is highly specific to MPNST and can help distinguish it from other sarcomas and spindle cell melanomas.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.