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Identifies the human epidermal growth factor receptor 2 (HER2/neu), a transmembrane tyrosine kinase receptor involved in cell growth and differentiation. HER2 overexpression or gene amplification is observed in a subset of breast, gastric, and other carcinomas and is associated with aggressive tumor behavior and poor prognosis. Detection is useful for prognosis and for selecting patients eligible for HER2-targeted therapies.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack but not in direct contact with specimen. Not suitable for freeze & hold option.