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A transmembrane tyrosine kinase receptor in the EGFR family, HER2 is overexpressed or amplified in various tumors, including breast and gastric cancers. HER2 status serves as both a prognostic and predictive marker and guides therapy with trastuzumab and other HER2-targeted agents.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.