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Identifies Kappa and lambda immunoglobulin light chains, which are expressed by plasma cells and plasmacytoid lymphocytes, and less reliably detected on B cells with small amounts of cytoplasm. This antibody is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin lymphomas. Demonstration of monotypism in lymphoid infiltrates is a surrogate for clonality, and therefore malignancy.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.