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Identifies a type II intermediate filament protein expressed in simple epithelia and their corresponding carcinomas. It is present in most glandular and ductal epithelial tissues, including liver, pancreas, lung, breast, and gastrointestinal tract. CK8 is commonly used to detect epithelial differentiation in tumors and distinguish carcinomas from non-epithelial neoplasms.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not indirect contact with specimen.