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Recognizes low molecular weight cytokeratins (CK8 and CK18) found in most simple epithelia and their derived carcinomas. It is useful for identifying epithelial origin in poorly differentiated tumors and is typically positive in adenocarcinomas of the lung, breast, and gastrointestinal tract, while negative in most sarcomas, lymphomas, and melanomas.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not indirect contact with specimen.