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Identifies the lambda light chain of immunoglobulins, useful in diagnosing leukemias, plasmacytomas, and certain non-Hodgkin lymphomas. A decreased kappa-to-lambda ratio indicates lambda light chain restriction, serving as a marker of B-cell clonality and malignancy.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.