Langerin

Identifies a type II transmembrane protein expressed in Langerhans cells. It is involved in the formation of Birbeck granules and antigen processing. Langerin is a useful marker for diagnosing Langerhans cell histiocytosis and distinguishing Langerhans cells from other dendritic or histiocytic cell populations.

Synonyms

Turnaround Time

24 Hrs

Methodology

IHC

Specimen Requirements

Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.

Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.

Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.

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Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

CPT Codes

88342x1 or 88341x1