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Identifies a nuclear transcription factor involved in the WNT/β-catenin signaling pathway, normally expressed in T cells and immature pro-B cells. LEF1 is highly expressed in CLL/SLL and is useful for distinguishing it from other small B-cell lymphomas such as mantle cell, marginal zone, and follicular lymphoma.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE )tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.