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Identifies a differentiation antigen expressed in melanocytes and serves as a sensitive and specific marker for melanoma. It recognizes a subcellular fraction found in melanosomes and is valuable in melanoma panels due to its specificity for melanocytic lesions. Melan A is typically co-expressed with HMB-45 in most melanomas but is also expressed in sex cord-stromal and adrenal cortical tumors, making it useful in distinguishing these neoplasms.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.