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Identifies a copper-containing metalloglycoprotein that serves as the rate-limiting enzyme in melanin synthesis. It is a marker of melanocytic cells and tumors and a target for cytotoxic T-cell recognition in melanoma. This antibody stains both melanotic and amelanotic melanomas, though it is generally less sensitive than HMB-45 and MART-1.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.