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Detects a mismatch repair protein essential for maintaining genomic stability. Mutations or loss of MLH1 expression are associated with microsatellite instability (MSI) and are seen in certain colonic, endometrial, gastric, ovarian, and breast carcinomas, as well as in some cases of acute lymphoblastic leukemia.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.