.png)
Identifies a mismatch repair protein involved in recognizing mismatched nucleotides during DNA replication. Loss of MSH2 expression leads to genomic instability and is associated with Lynch Syndrome–related tumors, as well as sporadic colorectal and other carcinomas with microsatellite instability (MSI).
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE )tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.