MSH6

Identifies one of the mismatch repair gene products. MSH6 mutations appear to be associated with atypical HNPCC and in particular with development of endometrial carcinoma or atypical endometrial hyperplasia, the presumed precursor of endometrial cancer. Loss of expression can help identify tumors in Lynch Syndrome patients, as well as identify MSI type sporadic colonic and other carcinomas. Loss of MSG6 is generally accompanied by simultaneous loss of MSH2, although selective loss of MSH6 can also be seen.