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Identifies methylthioadenosine phosphorylase, an enzyme involved in adenine and methionine salvage pathways. Loss of MTAP expression is commonly associated with homozygous deletion of the CDKN2A gene region on chromosome 9p21, seen in mesothelioma, glioma, and various.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
24 Hrs
Use cold pack for transport. Make sure cold pack is not indirect contact with specimen.