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Identifies a low-affinity nerve growth factor receptor expressed in Schwann cells, perineurial cells, melanocytes, and myoepithelial cells. It is a useful marker for identifying peripheral nerve sheath tumors, such as schwannomas and neurofibromas, and can help distinguish these from other spindle cell neoplasms. It also aids in detecting myoepithelial differentiation in salivary gland and breast tumors.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not indirect contact with specimen.