P53

Identifies the p53 tumor suppressor protein, which regulates cell proliferation and maintains genomic stability. Mutant p53 accumulates in cells, leading to loss of tumor-suppressor function and contributing to malignant transformation. Overexpression of p53 often correlates with underlying p53 mutations and can serve as a marker of malignancy. Elevated p53 levels have been linked to higher proliferative activity and poorer prognosis in cancers such as breast, colon, lung, brain, and certain leukemias and lymphomas.