PMS2

Identifies a DNA mismatch repair (MMR) protein involved in recruiting other repair factors to correct replication errors during cell division. Loss of PMS2 expression can indicate MLH1-related defects and is useful for detecting Lynch Syndrome–associated tumors, as well as sporadic colorectal and other cancers with microsatellite instability (MSI). PMS2 abnormalities account for a small but meaningful subset of colorectal cancers and are commonly seen in MSI-positive tumors.