Podoplanin (D240)

Identifies a 40kDa O-linked sialoglycoprotein expressed by a variety of tissues, including fetal testes and testicular germ cell tumors. Podoplanin is a marker of lymphatic endothelium, as well as neoplasms such as Kaposi's sarcoma. In the context of epithelial tumors, it has been demonstrated to be a highly sensitive marker of mesothelium and mesothelioma, complementing other markers such as calretinin and the Wilms tumor gene product. In neoplastic tissue, immunostaining of lymphatic endothelium can be useful in identifying lymphatic invasion of primary tumors.