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Preferentially expressed antigen in melanoma (PRAME) is detected in approximately 90% of melanoma subtypes, while it is negative in roughly 85% of cutaneous melanocytic nevi. Immunohistochemical detection of PRAME is useful as an adjunct diagnostic tool to help distinguish malignant melanoma from benign melanocytic lesions.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.