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Identifies Keratin 5/14, p63, and P504S to aid in the diagnosis of prostatic intraepithelial neoplasia (PIN) and prostate carcinoma, particularly in challenging or limited tissue samples. P504S highlights prostate adenocarcinoma and atypical adenomatous hyperplasia, while p63 and high–molecular weight cytokeratin mark the basal cells of normal and benign prostate glands, which are absent in malignancy.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.