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Identifies a tumor suppressor protein frequently lost or mutated in many cancers, including breast, prostate, and endometrial tumors, and in Cowden syndrome–associated lesions. Loss of PTEN expression can serve as a prognostic and predictive marker, correlating with more advanced disease in breast and prostate cancer. PTEN loss has also been associated with predicting response to Herceptin in HER2-positive breast cancers.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.