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Identifies the RB tumor suppressor protein, a key negative regulator of the cell cycle. Loss of RB function leads to uncontrolled cell proliferation. RB abnormalities are seen in a wide range of cancers, including breast, colon, prostate, kidney, nasopharyngeal tumors, and leukemias.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.