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Identifies the ROS1 proto-oncogene, which is highly expressed in various tumor cells. ROS1 gene rearrangements produce constitutively active fusion proteins found in ~1–2% of lung adenocarcinomas and are associated with strong responses to tyrosine kinase inhibitors such as crizotinib and ALK inhibitors. This antibody is useful as an alternative or complementary test to ROS1 FISH for detecting ROS1-rearranged lung adenocarcinomas.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.