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Identifies the succinate dehydrogenase complex subunit B (SDHB), a mitochondrial protein. Loss of SDHB expression by IHC indicates a mutation in any SDH subunit (SDHA, SDHB, SDHC, or SDHD) and is used in the evaluation of paragangliomas, pheochromocytomas, and gastrointestinal stromal tumors (GISTs) associated with SDH deficiency.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not indirect contact with specimen.