SMAD4

Loss of SMAD4 expression helps identify pancreatic ductal adenocarcinoma and some ampullary and colonic tumors, making it a useful marker in the evaluation of carcinomas of unknown primary.

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Synonyms

Turnaround Time

24 Hrs

Methodology

IHC

Specimen Requirements

Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.

Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.

Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.

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Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

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CPT Codes

88342x1 or 88341x1